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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What To Do For Multiple System Atrophy Causing Problem In Sleeping?

my dad has Multiple System Atrophy

one doctor gave him syndopa for almost 2 years

we changed a doctor to get a second opinion and this doc gave us BEXOL DT instead

after 4-5 months, he started having an increased tendency to fall. we thought it could be due to change in doctors

we went back to the old doctor and he put him back on syndopa again.

for the last 3 days since he has taken that, he is having a lot of issues including sleepiness, no energy, lack of sleep, hallucinations etc. we are confused what is causing all this. should he take one of these medicines or could he take both?
posted on Fri, 14 Mar 2014
Twitter Sun, 15 Feb 2015 Answered on
Twitter Mon, 16 Feb 2015 Last reviewed on
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Neurologist 's  Response
I read your question and I understand your concern.

The effects of these last 3 days are probably side effects of levodopa treatment. Perhaps a lower dose could be tried on that regard.
As for which is most appropriate between the two it is Syndopa which is normally use. However unfortunately in Multiple System Atrophy syndopa or any other drugs have little effect, so I wouldn't expect much improvement from treatment. Modern medicine hasn't advanced much in treating MSA I'm afraid.
For the falling issue, if it is in the setting of orthostatic hypotension (low blood pressure when changing position from supine to standing - common in MSA), then the most important thing is taking a lot of water, seems too simple but very important. There are also drugs like Fludrocortisone, Midodrine, Desmopressine, they all have their side effects though and should be prescribed carefully by a specialist. Posture education, physiotherapy also have their importance.

I hope to have been of help.
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What To Do For Multiple System Atrophy Causing Problem In Sleeping?

I read your question and I understand your concern. The effects of these last 3 days are probably side effects of levodopa treatment. Perhaps a lower dose could be tried on that regard. As for which is most appropriate between the two it is Syndopa which is normally use. However unfortunately in Multiple System Atrophy syndopa or any other drugs have little effect, so I wouldn t expect much improvement from treatment. Modern medicine hasn t advanced much in treating MSA I m afraid. For the falling issue, if it is in the setting of orthostatic hypotension (low blood pressure when changing position from supine to standing - common in MSA), then the most important thing is taking a lot of water, seems too simple but very important. There are also drugs like Fludrocortisone, Midodrine, Desmopressine, they all have their side effects though and should be prescribed carefully by a specialist. Posture education, physiotherapy also have their importance. I hope to have been of help.