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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Why Did My HDL Decrease And Lipoprotein Lp(a) Increase By 25% After Following A Plant-based Diet And Weight Loss?

Doctor, I am 57 yrs old/Female/155cms/85kgs , I am taking Tonac 10 regularly for Cholestrol. My blood test readings on 9.6.2024 is as below. HBA1C-7.1 Cholestrol-194, Triglyceride -135, HDL -46, LDL-121, VLDL-27, lipoprotein lpa a- 99 , APO lipoprot-121 and APO lipoprot-106 I went to a cardiologist to reduce lipo protienlpa a. He advised me Lipikind 20 and ask me to go for full plant diet and reduce weight. I followed his advice and reduced 3kgs in a month. My blood test readings on 13.7.24 is furnished below. HBA1C-6.3 Cholestrol-152, Triglyceride -119, HDL -42, LDL-86, VLDL-23.8, lipoprotein lpa a- 125 Why my HDL reduced and Lipo protein lpa increased 25% ? Please explain. Regards
posted on Wed, 24 Jul 2024
Twitter Mon, 7 Jul 2025 Answered on
Twitter Sun, 3 Aug 2025 Last reviewed on
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Dietitian & Nutritionist,  's  Response
Hello,

1. why HDL reduce
Answer- Weight loss and plant-based diets sometimes lower HDL temporarily because your body’s metabolism is changing. Additionally, Sometimes statins or other meds can also reduce HDL slightly.

2.Why did Lipoprotein (a) increase 25%?
Lipoprotein(a), or Lp(a), is a genetically determined lipid particles that does not usually respond well to lifestyle changes or standard cholesterol medications like statins and blood thinners. Also,Your cardiologist prescribed Lipikind 20 (likely a niacin derivative or another agent targeting lipids) which can sometimes help but results are variable or it can be temporary fluctuations due to diet and treatment.

You may raise a diet plan request from your dashboard and they will provide a personalized diet plan according to details and after clinical assessment. Dieticians are available 24/7 to assist to resolved and customized your diet plan

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Priyanka Singh, Dietitian & Nutritionist
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Why Did My HDL Decrease And Lipoprotein Lp(a) Increase By 25% After Following A Plant-based Diet And Weight Loss?

Hello, 1. why HDL reduce Answer- Weight loss and plant-based diets sometimes lower HDL temporarily because your body’s metabolism is changing. Additionally, Sometimes statins or other meds can also reduce HDL slightly. 2.Why did Lipoprotein (a) increase 25%? Lipoprotein(a), or Lp(a), is a genetically determined lipid particles that does not usually respond well to lifestyle changes or standard cholesterol medications like statins and blood thinners. Also,Your cardiologist prescribed Lipikind 20 (likely a niacin derivative or another agent targeting lipids) which can sometimes help but results are variable or it can be temporary fluctuations due to diet and treatment. You may raise a diet plan request from your dashboard and they will provide a personalized diet plan according to details and after clinical assessment. Dieticians are available 24/7 to assist to resolved and customized your diet plan Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Priyanka Singh, Dietitian & Nutritionist