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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Why Different Risk Factors Involved When There Is Rh Incompatibility Between Mother And Child?

1.     Prior to the development of Rhogam, a woman with blood type O- giving birth to a baby with blood type A+ had a 2% chance of developing an immune response and producing anti-Rh antibodies. A woman with blood type A- giving birth to a baby with blood type O+ had a 16% chance of immune response. Why do you think there such a large difference in risk?
Wed, 24 Jul 2013
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General & Family Physician 's  Response
Hi and thanks for the query,

There is an interplay of genetic factors and minor differences have been obtained between populations. The percentages generally given are from large scale studies. Differences always exist at individual and population levels. This explains why a cross match is always done even when blood groups and rhesus status are blood even before blood transfusions.

Thanks and hope this helps,

Bain LE, MD.
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Note: For detailed guidance on genetic screening consult a genetics specialist
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Why Different Risk Factors Involved When There Is Rh Incompatibility Between Mother And Child?

Hi and thanks for the query, There is an interplay of genetic factors and minor differences have been obtained between populations. The percentages generally given are from large scale studies. Differences always exist at individual and population levels. This explains why a cross match is always done even when blood groups and rhesus status are blood even before blood transfusions. Thanks and hope this helps, Bain LE, MD.