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Why Do My Testicles Still Hurt Weeks After Stopping Zoloft, And Could This Affect My Fertility Or Testosterone Production?
My testicles hurt since I ve tried to take Zoloft again I ve took only 5 pills, but they started hurting after the second one I am scared for my fertility, testosterone production etc. After the 5 pill I discontinued... I am in a fifth week of withdrawl and they are still hurting periodically. What happened, what can I do to fix it?
posted on
Wed, 6 Aug 2025
Medically reviewed by
Ask A Doctor - 24x7 Medical Review Team
Fri, 22 Aug 2025
Answered on
Mon, 1 Sep 2025
Last reviewed on
Hello,
Just relax, too much anxiety about fertility or testosterone can amplify the discomfort. Yes, studies have been done where Zoloft did lead to lower testosterone level. Since you have taken a short course of Zoloft (5 tablets) it is likely that it will not cause permanent damage to testicles, sperm production, or testosterone levels.
Your pain and discomfort are more likely related to local irritation, muscle tension, or nerve sensitivity. Pelvic floor muscles become tense during SSRI use and remain that way, causing intermittent pain. Stretching exercises will be helpful. Wearing a supportive underwear will help.
Since I find you to be very worried, you can get a semen analysis and testosterone blood test done for reassurance and peace of mind. However, if symptoms persist, you are advised to get clinically examined by a local urologist to rule out other testicular pathology that may be causing you symptoms.
Take care. Hope I have answered your question. Let me know if I can assist you further.
Regards,
Dr Nupur K., General & Family Physician
Just relax, too much anxiety about fertility or testosterone can amplify the discomfort. Yes, studies have been done where Zoloft did lead to lower testosterone level. Since you have taken a short course of Zoloft (5 tablets) it is likely that it will not cause permanent damage to testicles, sperm production, or testosterone levels.
Your pain and discomfort are more likely related to local irritation, muscle tension, or nerve sensitivity. Pelvic floor muscles become tense during SSRI use and remain that way, causing intermittent pain. Stretching exercises will be helpful. Wearing a supportive underwear will help.
Since I find you to be very worried, you can get a semen analysis and testosterone blood test done for reassurance and peace of mind. However, if symptoms persist, you are advised to get clinically examined by a local urologist to rule out other testicular pathology that may be causing you symptoms.
Take care. Hope I have answered your question. Let me know if I can assist you further.
Regards,
Dr Nupur K., General & Family Physician
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