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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Why Should Magnesium Hydroxide And Ranitidine Be Taken At Different Timings?

why are these given in a separate time Magnesium hydroxide/aluminum hydroxide (Mylanta) 15 mL PO 1 hour before bedtime and 3 hours after mealtime and at bedtime.
Ranitidine (Zantac) 300 mg PO at bedtime.
Sucralfate/Carafate 1 g or 10ml suspension (500mg / 5mL) 1 hour before meals and at bedtime.
Mon, 7 Nov 2016
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General & Family Physician,  's  Response
Hi & Welcome.

All antacids including Mylanta (magnesium hydroxide/aluminium hydroxide) may affect the absorption of Ranitidine by binding the drug (reducing its absorption) or by increasing the stomach pH so that the drug’s dissolution or solubility is altered. hence should be taken at different times.

Similarly taking Sucralfate together with antacid can decrease the effects of sucralfate. Sucralfate and antacid therefore should be separated by at least half an hour.

Hope this answers your query.
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Why Should Magnesium Hydroxide And Ranitidine Be Taken At Different Timings?

Hi & Welcome. All antacids including Mylanta (magnesium hydroxide/aluminium hydroxide) may affect the absorption of Ranitidine by binding the drug (reducing its absorption) or by increasing the stomach pH so that the drug’s dissolution or solubility is altered. hence should be taken at different times. Similarly taking Sucralfate together with antacid can decrease the effects of sucralfate. Sucralfate and antacid therefore should be separated by at least half an hour. Hope this answers your query.