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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Why Won T My 1.5-year Yeast Infection Improve Despite Multiple Antifungals And Antibiotics?

Hi I have a yeast infection for 1.5 years I took fluconazole tablet everytime I get and itraconazole also and miconazole suppository still doesn t work an I getting it from my partner I did a vaginal swab it shows gram neg bacilli and second time it shows coagulase negative staph and once I took Doxycyclinefor 5 days and metronidazole for 5 days still there is no improvement all my blood test are normal including virology
posted on Wed, 3 Jan 2024
Twitter Mon, 21 Jul 2025 Answered on
Twitter Sun, 3 Aug 2025 Last reviewed on
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General & Family Physician,  's  Response
Hello,

You have a chronic infection. You are advised to get clinically examined by a gynecologist or infectious disease specialist. Get done vaginal culture for fungus and bacterial pathogens. Also get done culture sensitivity for BV, trichomoniasis testing. Panel tests for vaginitis, STD testing should also be done.

The male partner is advised to use antifungal cream (clotrimazole) for 1–2 weeks even if asymptomatic. He should use condoms until both are clear. Maintain genital hygiene but don’t over do with the washing and cleanliness. Soft, loose-fitting cotton clothes are the best until recovery. Daily probiotic supplements (oral or vaginal) will help with healing and to restore balance. Avoid unprotected sex during treatment.

Your treatment will depend on the infection diagnosed. Some self-treat “yeast” but actually have bacterial vaginosis (BV), aerobic vaginitis (AV), desquamative vaginitis, or even lichen sclerosus. You are advised to get all tests done first, before taking oral medicines or applying ointments. Chronic infections may take a longer time to be treated.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Nupur K., General & Family Physician
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Why Won T My 1.5-year Yeast Infection Improve Despite Multiple Antifungals And Antibiotics?

Hello, You have a chronic infection. You are advised to get clinically examined by a gynecologist or infectious disease specialist. Get done vaginal culture for fungus and bacterial pathogens. Also get done culture sensitivity for BV, trichomoniasis testing. Panel tests for vaginitis, STD testing should also be done. The male partner is advised to use antifungal cream (clotrimazole) for 1–2 weeks even if asymptomatic. He should use condoms until both are clear. Maintain genital hygiene but don’t over do with the washing and cleanliness. Soft, loose-fitting cotton clothes are the best until recovery. Daily probiotic supplements (oral or vaginal) will help with healing and to restore balance. Avoid unprotected sex during treatment. Your treatment will depend on the infection diagnosed. Some self-treat “yeast” but actually have bacterial vaginosis (BV), aerobic vaginitis (AV), desquamative vaginitis, or even lichen sclerosus. You are advised to get all tests done first, before taking oral medicines or applying ointments. Chronic infections may take a longer time to be treated. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Nupur K., General & Family Physician