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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Will The Use Of Syndopa Plus Lead To Drug-induced Psychosis?

Dear Doctor,
My sister is 65 years old. She has been advised to take Syndopa Plus after being diagnosed of Parkinson's disease (Bradykinesia). However, I am very worried about starting on the drug because I have read it could lead to drug-induced psychosis. There is a history of psychiatric illnesses in my family, my brother (57 years old) has been a schizophrenic patient for the last 37 years. Please advice whether my apprehensions are genuine or ill-founded.
Tue, 25 Mar 2014
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Psychiatrist 's  Response
Welcome to hcm!

your information.is correct about the possibility of syndopa inducing psychosis in.patients. However, it is only a risk but one has to treat parkinsons also. There are other meds available to treat parkinsons but syndopa is the first line managment.
Please do not fear so much, just keep a check on het mood/ behaviour / symptoms after starting the mediicne. She might remain fine, as not every patient develops psychosis on it.

She never had a history of psychiatric illness herself and you also did not mention that your parents ever had it. so for.her risk is not significant.
i would advice that you start with low dose of syndopa amd monitor.response. Make regular follow ups with doctor.

Wish you good luck
Dr. Manisha Gopal
MD Psychiatry
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Will The Use Of Syndopa Plus Lead To Drug-induced Psychosis?

Welcome to hcm! your information.is correct about the possibility of syndopa inducing psychosis in.patients. However, it is only a risk but one has to treat parkinsons also. There are other meds available to treat parkinsons but syndopa is the first line managment. Please do not fear so much, just keep a check on het mood/ behaviour / symptoms after starting the mediicne. She might remain fine, as not every patient develops psychosis on it. She never had a history of psychiatric illness herself and you also did not mention that your parents ever had it. so for.her risk is not significant. i would advice that you start with low dose of syndopa amd monitor.response. Make regular follow ups with doctor. Wish you good luck Dr. Manisha Gopal MD Psychiatry