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Can Fluoxetine HCL, Venlafaxine And Bupropion Be Taken Together?

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Posted on Fri, 4 Mar 2016
Twitter Fri, 4 Mar 2016 Answered on
Twitter Fri, 13 May 2016 Last reviewed on
Question : CAN YOU TAKE FLUOXETINE HCL, VENAFAXINE HCL ER, AND BUPROPION HCL XL TOGETHER XXXX
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Answered by Dr. Panagiotis Zografakis (36 minutes later)
Brief Answer:
you'd rather not!

Detailed Answer:
Hello,

all three of them interact with each other. Bupropion usage with any of the others may increase the risk for seizures in a dose-dependent fashion. Concurrent use of venlafaxine and fluoxetine increases the risk of serotonin syndrome which is potentially fatal. So you'd rather not use these drugs together.

Kind Regards!
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3815 Questions

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Can Fluoxetine HCL, Venlafaxine And Bupropion Be Taken Together?

Brief Answer: you'd rather not! Detailed Answer: Hello, all three of them interact with each other. Bupropion usage with any of the others may increase the risk for seizures in a dose-dependent fashion. Concurrent use of venlafaxine and fluoxetine increases the risk of serotonin syndrome which is potentially fatal. So you'd rather not use these drugs together. Kind Regards!