question-icon

Can Harvoni Be Taken When On Methadone?

default
Posted on Wed, 28 Jan 2015
Twitter Wed, 28 Jan 2015 Answered on
Twitter Wed, 25 Feb 2015 Last reviewed on
Question : Good AM. I presently am on a methadone maintenance program, and have been for many years. The Dr. At the program feels that I should go up on the dosage because I will start taking Harvoni Feb 1, 2015. What are your feelings about that?
doctor
Answered by Dr. Dr. Matt Wachsman (1 hour later)
Brief Answer:
the changes are supposed to be SMALL

Detailed Answer:
Methadone changes are highly regulated. They should not change it upward even 15% at a time.

also,
"NS5B nucleos(t)ide analog inhibitors (i.e., sofosbuvir) and some HCV NS5A inhibitors (i.e., ledipasvir), which do not or only marginally affect CYP450, are relatively free of significant pharmacokinetic interactions. "
Expert Opin Drug Metab Toxicol. 2015 XXXXXXX 2:1-9. [Epub ahead of print]

there's nothing out there specific for this particular drug interaction... but you really would NOT expect a problem with it and you would NOT expect a need to increase the methadone.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Dr. Matt Wachsman

Addiction Medicine Specialist

Practicing since :1985

Answered : 4211 Questions

Ask me a question
premium_optimized

The User accepted the expert's answer

Ask an Internal Medicine Specialist
Share on

Get personalised answers from verified doctor in minutes across 80+ specialties

159 Doctors Online

By proceeding, I accept the Terms and Conditions

HCM Blog Instant Access to Doctors
HCM Blog Questions Answered
HCM Blog Satisfaction
backtotop2
Can Harvoni Be Taken When On Methadone?

Brief Answer: the changes are supposed to be SMALL Detailed Answer: Methadone changes are highly regulated. They should not change it upward even 15% at a time. also, "NS5B nucleos(t)ide analog inhibitors (i.e., sofosbuvir) and some HCV NS5A inhibitors (i.e., ledipasvir), which do not or only marginally affect CYP450, are relatively free of significant pharmacokinetic interactions. " Expert Opin Drug Metab Toxicol. 2015 XXXXXXX 2:1-9. [Epub ahead of print] there's nothing out there specific for this particular drug interaction... but you really would NOT expect a problem with it and you would NOT expect a need to increase the methadone.