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Can Harvoni Be Taken When On Methadone?

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Posted on Wed, 25 Feb 2015
Question: Good AM. I presently am on a methadone maintenance program, and have been for many years. The Dr. At the program feels that I should go up on the dosage because I will start taking Harvoni Feb 1, 2015. What are your feelings about that?
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Answered by Dr. Dr. Matt Wachsman (1 hour later)
Brief Answer:
the changes are supposed to be SMALL

Detailed Answer:
Methadone changes are highly regulated. They should not change it upward even 15% at a time.

also,
"NS5B nucleos(t)ide analog inhibitors (i.e., sofosbuvir) and some HCV NS5A inhibitors (i.e., ledipasvir), which do not or only marginally affect CYP450, are relatively free of significant pharmacokinetic interactions. "
Expert Opin Drug Metab Toxicol. 2015 XXXXXXX 2:1-9. [Epub ahead of print]

there's nothing out there specific for this particular drug interaction... but you really would NOT expect a problem with it and you would NOT expect a need to increase the methadone.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Dr. Matt Wachsman

Addiction Medicine Specialist

Practicing since :1985

Answered : 4214 Questions

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Can Harvoni Be Taken When On Methadone?

Brief Answer: the changes are supposed to be SMALL Detailed Answer: Methadone changes are highly regulated. They should not change it upward even 15% at a time. also, "NS5B nucleos(t)ide analog inhibitors (i.e., sofosbuvir) and some HCV NS5A inhibitors (i.e., ledipasvir), which do not or only marginally affect CYP450, are relatively free of significant pharmacokinetic interactions. " Expert Opin Drug Metab Toxicol. 2015 XXXXXXX 2:1-9. [Epub ahead of print] there's nothing out there specific for this particular drug interaction... but you really would NOT expect a problem with it and you would NOT expect a need to increase the methadone.