Can Unisom Be Taken With Zoloft?

Posted on Sat, 5 Sep 2015

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Sat, 5 Sep 2015 Answered on

Mon, 28 Sep 2015 Last reviewed on

Question : can I take unisom with zoloft

Answered by Dr. Bonnie Berger-Durnbaugh (42 minutes later)

Brief Answer:
The two together may compound sleepiness.

Detailed Answer:
Unisom is the antihistamine doxylamine. Zoloft is sertraline. I ran a search to see about any interactions between the two.

What I found was that you can take them together - no absolute contraindications - BUT you may get side effects from the combination.

The combination can cause:
- increased dizziness, drowsiness, and difficulty concentrating
- some impairment in thinking and judgment

Do not drink alcohol with this combination.

Also, you should probably not drive until you know how the combo will affect you.

I hope this information helps.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar