Brief Answer: It's not advisable to stop Aspirin Detailed Answer: Hi Welcome to Healthcare-Magic Greetings of the day Dear XXXX I would suggest you to go as per recommendations of your Physician. Let me explain you the reasons. Mechanism of action of drugs 1. Xarelto is Rivaroxaban which is oral anticoagulant, it act by direct inhibition of Factor Xa ( One of the anticoagulant factor). It acts by inhibiting the final step of coagulation leading on to thrombus formation 2. Aspirin is an anti platelet drug which acts by inhibiting platelet aggregation. Mechanism of action is by inhibiting the enzyme Cylcooxygenase which is present in Platelets and which helps in synthesis of various factors which helps in Platelet aggregation and plugging by Platelet. As the two drugs act by different mechanism, combined use of it causes synergistic action and achieves thrombus prevention which is not possible when the drugs are used separately. The need for such combination depends on the indication for which anticoagulation is required. If the benefits of achieving anticoagulation is more than the slight probability and risk of increased bleeding can be taken. Also the degree of anticoagulation can be monitored by certain laboratory investigation and if the reference of the values are maintained within prescribed limit than risk of major bleeding is very much reduced. 1. Bleeding time 2. Prothrombin time ( PT ) 3. Activated Partial Thromboplastin time ( APTT ) If these values are within the range than there is no cause for concern. I would suggest you to go by recommendations of your Physician. In case you require any further assistance, will be glad to assist you. Take care Best Regards Dr T Shobha Deepak MBBS, MD

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