Brief Answer: Maintain two hour gap between the two Detailed Answer: Hi Thanks for using healthcare magic. I, Dr Abhishek Kapoor, would help you in this query. There is no major interaction between probiotics and xanax. Though, Probiotics are microorganisms and they effect on absorption, so they should be minimum two hour gap between them. If you are taking xanax for sleep, then take probiotics during day time and xanax at night. If you are taking xanax for anxiety even during day time, then take it at least two hours before probiotic to avoid any effect on its absorption. In case, you need further help, you can ask. Regards Dr. Abhishek Kapoor Psychiatrist

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