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What Causes Abnormal TSH Levels Despite Taking Synthroid?

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Posted on Thu, 10 Sep 2015
Question: What would atribute a Tsh of abnormal range 0000 be continous for almost 9 moths, My Sybthroid has been decreased four times with nochange down to 25 mg
doctor
Answered by Dr. Shehzad Topiwala (46 minutes later)
Brief Answer:
Thyroid

Detailed Answer:
I follow what you are saying.

Thyroid management can be complex and is best handled by a trained endocrinologist in person.

When I see someone in my practice with similar laboratory results, I order the following tests in addition to a thorough physical examination:

CBC
CMP
TSH
Free T4
Total T3
T3 resin uptake
anti TPO antibodies
anti Thyroglobulin antibodies
Prolactin
FSH
LH
8 am serum cortisol

It is possible that on that basis of findings on physical examination I may order fewer tests or more tests.

There is an uncommon condition called Central or Secondary Hypothyroidism that needs to be ruled out.

Moreover, there are certain types of medications that tend to lower the TSH such as steroids and opioids.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Shehzad Topiwala (26 minutes later)
Would you consider hunchimoto disase that may be affecting the thyroind galnd?
doctor
Answered by Dr. Shehzad Topiwala (3 hours later)
Brief Answer:
Follow up

Detailed Answer:
You are probably referring to Hashimoto's disease.

Yes it is one of the most commonest causes for a permanently under-active thyroid, necessitating lifelong treatment with levo thyroxine (of which Synthroid is one brand name medication).

The two antibody tests mentioned above are helpful is diagnosing this condition. Other indications as to whether it is present come from physical examination.
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
Dr.
Dr. Shehzad Topiwala

Endocrinologist

Practicing since :2001

Answered : 1663 Questions

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What Causes Abnormal TSH Levels Despite Taking Synthroid?

Brief Answer: Thyroid Detailed Answer: I follow what you are saying. Thyroid management can be complex and is best handled by a trained endocrinologist in person. When I see someone in my practice with similar laboratory results, I order the following tests in addition to a thorough physical examination: CBC CMP TSH Free T4 Total T3 T3 resin uptake anti TPO antibodies anti Thyroglobulin antibodies Prolactin FSH LH 8 am serum cortisol It is possible that on that basis of findings on physical examination I may order fewer tests or more tests. There is an uncommon condition called Central or Secondary Hypothyroidism that needs to be ruled out. Moreover, there are certain types of medications that tend to lower the TSH such as steroids and opioids.