Brief Answer:
Stress has led to relapse
Detailed Answer:
Hello,
Thanks for choosing health care magic for posting your query.
I have gone through your question in detail and I can understand what you are going through.
Its unfortunate that after such a good control of depressive symptoms for 14 years with Effexor 150mg, you had a relapse and that too this severe. There could be two reasons for such a phenomenon:
1) There is a relapse of
depression when there is a stress which could not be managed by the body/mind. A surgical procedure even though elective is a psychological and physical stressor and can cause a relapse of depression.
2) The other possibility is that, the drugs given during
anesthesia are mostly metabolized in the liver and also alter the
metabolism of liver to some extent. Now even the effexor is metabolized in the liver and hence this change in metabolism might have affected the blood levels of effexor, leading to a relapse and resistance. This change in metabolism rate is temporary and over a period of time things should settle down. But until now it would be wise changing the medicines as there is so much distress.
There may not be any "receptor damage" or "rendering the effexor useless with some endogenous trigger" phenomenon.
Now that effexor 300mg and welbutrin is not benefiting you, it might be wise to start a
mood stabilizer drug along with the existing drugs. Mood stabilizers such as
Lamotrigine or Valpraote may be useful with such resistant cases. Valproate will be my choice of medicine in such cases.
Also you may augment Cognitive behavioural therapy along with these medicines. This therapy is taken by either a
psychologist or a
psychiatrist in which the therapist identifies impaired cognitions (Thoughts) and try to correct them. They are 15-20 min weekly session and there should be around 8-10 sessions to help you with your illness.
Hope I am able to answer your concerns.
If you have any further query, I would be glad to help you.
If not, you may close the discussion and if possible you may rate the answer for me, so that I get a good feedback.
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Wish you good health,
Kind regards
Dr. Srikanth Reddy M.D.
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