Hi, Welcome to Healthcare Magic Forum. I have gone through your Query & I really appreciate your concern about the problem you are facing. As a physician i would like to tell you that there is no known drug interaction between Benadryl and Xarelto 20mg. So you can take the drug without any queries in your mind. I would also like to tell you that when Benadryl & Lisinopril 10mg are taken togather they may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. Thanks for Trusting & Posting your Query on this forum. Hope this will help you. Feel free to ask any further question. Have a nice Day. Regards, Dr.Abhijeet