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Can Dosage Of 6-MP Be Decreased While Undergoing Leukemia Treatment?
my brother s is a leukemia patient .he is 4 years and 2 months old . currently he is undergoing final mentainanace ttt with MTX and 6-MP . along with septran .his current SGPT is 77 U/L while his SGOT is 48 U/L please could you tell me if we should decrease his dosage of 6-MP ?
posted on
Fri, 14 Mar 2014
Medically reviewed by
Ask A Doctor - 24x7 Medical Review Team
Tue, 6 Oct 2015
Answered on
Wed, 7 Oct 2015
Last reviewed on
Hi,
6 MP(Mercaptopurine) is stopped when total bilirubin levels are more than 2 mg/d or SGOT, SGPT >200.
However, in patients of leukemia this is not the only criteria, we have to also look for absolute neutrophil count, and any associated complications like pancreatitis.
If I was treating your brother, then I have kept this things in mind also. If only SGOT and SGPT are in range of 70 to 80,then there is no need to decrease 6 MP.
I hope this has helped you.
Wishing your brother good health.
6 MP(Mercaptopurine) is stopped when total bilirubin levels are more than 2 mg/d or SGOT, SGPT >200.
However, in patients of leukemia this is not the only criteria, we have to also look for absolute neutrophil count, and any associated complications like pancreatitis.
If I was treating your brother, then I have kept this things in mind also. If only SGOT and SGPT are in range of 70 to 80,then there is no need to decrease 6 MP.
I hope this has helped you.
Wishing your brother good health.
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