HELLO & WELCOME TO HCM FORUM
Factors Known to Cause False-Positive HIV Antibody Test Results
•     Anti-carbohydrate antibodies 
•     Naturally-occurring antibodies 
•     Passive immunization: receipt of gamma globulin or immune globulin (as prophylaxis against infection which contains antibodies)
•     Leprosy 
•     Tuberculosis (YOUR PROBLEM)
•     Mycobacterium avium
•     Systemic 
lupus erythematosus 
•     Renal (kidney) failure 
•     Hemodialysis/renal failure 
•     Alpha interferon therapy in hemodialysis patients
•     Flu 
•     Flu vaccination
•     Herpes simplex I 
•     Herpes simplex II 
•     Upper respiratory tract infection (cold or flu)
•     Recent viral infection or exposure to viral vaccines 
•     Pregnancy in multiparous women 
•     Malaria
•     High levels of circulating immune complexes 
•     
Hypergammaglobulinemia (high levels of antibodies)
•     False positives on other tests, including RPR (rapid plasma reagent) test for syphilis
•     
Rheumatoid arthritis 
•     Hepatitis B vaccination 
•     Tetanus vaccination
•     Organ transplantation
•     Renal transplantation 
•     Anti-lymphocyte antibodies
•     Anti-collagen antibodies (found in gay men, haemophiliacs, Africans of both sexes and people with leprosy)
•     Serum-positive for rheumatoid factor, antinuclear antibody (both found in rheumatoid arthritis and other autoantibodies)
•     Autoimmune diseases : Systemic lupus erythematosus, scleroderma, connective tissue disease, dermatomyositis
•     Acute viral infections, DNA viral infections
•     Malignant neoplasms (cancers)
•     Alcoholic hepatitis/
alcoholic liver disease 
•     
Primary sclerosing cholangitis 
•     Hepatitis 
•     "Sticky" blood (in Africans) 
•     Antibodies with a high affinity for polystyrene (used in the test kits)
•     Blood transfusions, multiple blood transfusions
•     Multiple myeloma 
•     HLA antibodies (to Class I and II leukocyte antigens)
•     Anti-smooth muscle antibody 
•     Anti-parietal cell antibody
•     Anti-hepatitis A IgM (antibody)
•     Anti-Hbc IgM 
•     Administration of human immunoglobulin preparations pooled before 1985 
•     Haemophilia 
•     Haematologic malignant disorders/lymphoma 
•     
Primary biliary cirrhosis 
•     Stevens-Johnson syndrome9,
•     Q-fever with associated hepatitis 
•     Heat-treated specimens 
•     Lipemic serum (blood with high levels of fat or lipids)
•     Haemolyzed serum (blood where haemoglobin is separated from the red cells)
•     Hyperbilirubinemia
•     Globulins produced during polyclonal gammopathies (which are seen in AIDS risk groups)
•     Healthy individuals as a result of poorly-understood cross-reactions 
•     Normal human ribonucleoproteins 
•     Other retroviruses (YOUR PROBLEM)
•     Anti-mitochondrial antibodies 
•     Anti-nuclear antibodies 
•     Anti-microsomal antibodies 
•     T-cell leukocyte antigen antibodies 
•     Proteins on the filter paper 
•     Epstein-Barr virus 
•     
Visceral leishmaniasis 
•     Receptive anal sex
HIV RNA PCR IS SPECIFIC FOR HIV AND WILL NOT BE HINDERED BY ANY OTHER HTLV/ TB
THIS TEST IS USED TO DIAGNOSE WHENEVER WESTERN BLOT TEST IS NON SPECIFIC.
TAKE CARE
DR. MAYANK BHARGAVA