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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Could High Bilirubin And Ast Be Due To Replacing Simvastatin With Atovastation?

doc. i am a va. patient, my doctor retired. have new doctor, she has taken me off 80mg simvastatin and replaced it with 80mg atorvastation now 9 months later had blood work . my t bili is high 1.40. my ast high 53. i was on simvastatin 80mg and blood work was always in range. i am concerned. thank you
Tue, 18 Mar 2014
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Internal Medicine Specialist,  's  Response
Hi, Increase in liver enzymes and liver inflammation (hepatitis) is one of the side effects of statin medications. Your liver tests are currently mildly elevated and if I was seeing you as a patient, I would recommend repeating your blood tests in 3-4 months to ensure that they are not continuing to go up. Meanwhile, if you notice any abdominal pain, yellowing of the skin or eyes, dark urine or light stools, itching, muscle pains that do not go away, these could be due to atorvastatin. I would recommend at that time you stop the medicine and call your physician right away. I would also discuss with your physician your concerns about the liver tests and atorvastatin.
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Could High Bilirubin And Ast Be Due To Replacing Simvastatin With Atovastation?

Hi, Increase in liver enzymes and liver inflammation (hepatitis) is one of the side effects of statin medications. Your liver tests are currently mildly elevated and if I was seeing you as a patient, I would recommend repeating your blood tests in 3-4 months to ensure that they are not continuing to go up. Meanwhile, if you notice any abdominal pain, yellowing of the skin or eyes, dark urine or light stools, itching, muscle pains that do not go away, these could be due to atorvastatin. I would recommend at that time you stop the medicine and call your physician right away. I would also discuss with your physician your concerns about the liver tests and atorvastatin.