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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Feeling Nauseous After Taking Two Amitriptyline (Endep) Tablets For Anxiety. Suggestions?

HI DR I HAVE BEEN ON AMITRIPTYLINE, { ENDEP} FOR SOMETIME HAVE BEEN TAKING 2X25 MG AT NIGHT , THOUGHT I WOULD GO BACK TO 1X25 AS STATES I CAN TAKE 1 OR 2 ON SCRIPT , BUT I HAVE BEEN FEELING TERRIBLE NAUSIUS WHICH I STARTED TAKING ENDEP FOR { ANXIETY}, ANY SUGESTIONS WHY, SHOULD I GO BACK TO 2 AGAIN, THANKS KAY
posted on Mon, 13 May 2013
Twitter Mon, 13 May 2013 Answered on
Twitter Mon, 13 May 2013 Last reviewed on
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Internal Medicine Specialist,  's  Response
Hi
Severe nausea is a side effect of AMITRIPTYLINE. It is due to its anticholinergic activity. It is can be combated by taking Domperidone 10 0r 20 mg 3 times daily before taking food. If not getting relief you need to consider to change ENDEP to some other antianxiety medications in consultation with your doctor.
Regards
Ranjit
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Psychiatrist,  Dr. Ashish Mittal's  Response
Hello,
welcome to Healthcare Magic.

Amitriptyline is associated with nausea, acidity, constipation and drowsiness at initiation of treatment. Usually these side effects stopped occurring after continuation of treatment.

25 mg Amitriptyline is low dose, to be effective for anxiety. Reason for dose reduction is not clear from your history. Low dose can also lead to recurrence of anxiety symptoms.

If you are not tolerating Amitriptyline well, then you can meet your psychiatrist for reevaluation. You can also request for newer medicine to control your anxiety like: SSRIs and Mirtazapine.

Wishing you good health and all the best.

Regards,
Dr Ashish Kumar Mittal
www.99doctor.com
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Feeling Nauseous After Taking Two Amitriptyline (Endep) Tablets For Anxiety. Suggestions?

Hi Severe nausea is a side effect of AMITRIPTYLINE. It is due to its anticholinergic activity. It is can be combated by taking Domperidone 10 0r 20 mg 3 times daily before taking food. If not getting relief you need to consider to change ENDEP to some other antianxiety medications in consultation with your doctor. Regards Ranjit