My wife has PD. It is very difficult to take any of the meds, as she has all of the adverse side-effects when taking. One that seems in common is severe burning of her skin, while feeling chilled. The last was Cogentin, for a few day it seemed to help, then the side effects, nausea, memory loss, hives, shaking was helped but got worse, stiffness to the point of immobility. Our Drs. are at a loss as to why she can't take the meds. We don't know where to turn next.