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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Have Bruise On The Thighs. Positive ANA. Have Muscle Pain, Fatigue, Blood In Urine. Positive For MTHFR. Bruise Impact Of MTHFR?

I have noticed unexplained bruising on my thighs (currently a total of 5 bruises). I have tested with a positive ANA (low positive) and have suffered from muscle pain and fatigue for the past 5 years, with no firm diagnosis. I also have had unexplained blood in my urine, but have had a full work up on my bladder (CT and cystoscopy), with no material findings (my mother also has this). A full CBC run just a few months ago was normal, except for the ANA. I have also tested postive for the Smith antibody and am positive for MTHFR. Is this bruising possibly related to an auto immune condition? Does the MTHFR have an impact? I am not on any medication, but do take a B12 and folic acid daily. I also took a very small dosage for predisone about 4 weeks ago, to help relieve inflammation from a back injury (twisted too much in yoga). Not sure if the predisone could cause bruising so much later?
posted on Thu, 20 Jun 2013
Twitter Thu, 20 Jun 2013 Answered on
Twitter Fri, 21 Jun 2013 Last reviewed on
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Pediatrician,  's  Response
hello.thanks for using healthcaremagic.auto immune condition can cause bruising by platelet destruction.
but since you had one episode of blood in urine,i will recommend you to consult hematologist.. he may advice you to go for complete coagulation assay..since you are positive for MTHFR you should take active form of folic acid like l-methyl folate.it is less likely that steroid causes bruising so lately...hope i have answered your querries satisfactorily..have a nice day ahead..
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Have Bruise On The Thighs. Positive ANA. Have Muscle Pain, Fatigue, Blood In Urine. Positive For MTHFR. Bruise Impact Of MTHFR?

hello.thanks for using healthcaremagic.auto immune condition can cause bruising by platelet destruction. but since you had one episode of blood in urine,i will recommend you to consult hematologist.. he may advice you to go for complete coagulation assay..since you are positive for MTHFR you should take active form of folic acid like l-methyl folate.it is less likely that steroid causes bruising so lately...hope i have answered your querries satisfactorily..have a nice day ahead..