Hi,I am Dr. Amitkumar Sharma (Internal Medicine Specialist). I will be looking into your question and guiding you through the process. Please write your question below.
Have Low ACTH, Hashimoto Thyroiditis And Post Menopausal. On Diflucan And Fungal Cream. Will The Medicines Contradict?
Hello
I was on diflucan and fungal cream (topical) for tinea versicolor and my ACTH was low and my estrogen raised. I jave addison diseases, Hashimoto Thyroiditis and post menopausal. Their is conflicting information about how antifungals are cytochrome inhibtors or inducers. I always learned in medical school (nursing) it was from inhibitor so other meds like my hydrocortisone and florinef i take for Addisons will build up due to inhibiting the enzymes.
Hi, Welcome to HCM, You have addison disease and Hashimoto Thyroiditis. Now for fungal infection you have been prescribed Fluconazole(Diflucan). I am happy to know you take care of your health and keep knowledge of drug interaction. Let me explain you Fluconazole is an inhibitor of the human cytochrome P450 system, CYP3A4 to lesser extent. In theory, therefore, fluconazole decreases the metabolism and increases the concentration of any drug metabolised by these enzymes. fluconazole + fludrocortisone & fluconazole + hydrocortisone fluconazole will increase the level or effect of fludrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. But antifungal are given for short time and topical cream is safe. Please take care. Dr.Akhilesh Dubey m.D.
I find this answer helpful
2 users find this helpful
You found this answer helpful
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer.
For a more detailed, immediate answer, try our premium service
[Sample answer]
We use cookies in order to offer you most relevant experience and using this website you acknowledge that you have already read and understood our
Privacy Policy
Have Low ACTH, Hashimoto Thyroiditis And Post Menopausal. On Diflucan And Fungal Cream. Will The Medicines Contradict?
Hi, Welcome to HCM, You have addison disease and Hashimoto Thyroiditis. Now for fungal infection you have been prescribed Fluconazole(Diflucan). I am happy to know you take care of your health and keep knowledge of drug interaction. Let me explain you Fluconazole is an inhibitor of the human cytochrome P450 system, CYP3A4 to lesser extent. In theory, therefore, fluconazole decreases the metabolism and increases the concentration of any drug metabolised by these enzymes. fluconazole + fludrocortisone & fluconazole + hydrocortisone fluconazole will increase the level or effect of fludrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. But antifungal are given for short time and topical cream is safe. Please take care. Dr.Akhilesh Dubey m.D.