Good morning, IsAgenics is a multi-level marketing program for supplements launched by a fellow who worked in the supplement business and a person who specialized in multi-level marketing plans. I see no mention of biochemists, scientists or other credible people at the helm. The following is the opinion of another agency in evaluation of this product and contained on the Wickipedia page: According to a report by Australian consumer organization CHOICE the company s nutritional cleansing product makes claims which are not supported by science. Additionally, other Isagenix s weight-loss products are similar in content to much cheaper store-bought alternatives. The report also describes instances of unqualified associates providing medical advice about the products, which is prohibited by the company. Cholesterol recommendations, although controversial, are advised to remain below 200 mg/dl per day, so depending on what you mixed the 80 mg of cholesterol laden shake with, you can stay under that amount if you avoid most animal products the rest of the day. I would never approve of continuation of this plan. Look at a complete change in your lifestyle, mind/body/spirit. If you would like personalized help please feel free to come to me via my specialist portal and we can work on a personalized plan for you. Respectfully, Kathryn J. Shattler, MS,RDN