Histiocytosis is a general name for a group of disorders or syndromes that involve an abnormal increase in the number of immune cells that are called histiocytes. Symptoms in adults may include: Bone pain Chest pain Cough Fever General discomfort, uneasiness, or ill feeling Increased amount of urine Rash Shortness of breath Thirst and increased drinking of fluids Weight loss. As per your explaination, your daughter have more of sinal pain that could be related to bone pain due to histocytosis also. If MRI scan report is normal then I suggest to discuss with your doctor for possible treatment option for histocytosis. For spinal pain I suggest she can visit a physiotherapist and take physiotherapy treatment and also follow spinal exercises which includes strengthening, stretching, twisting of spine. This will help to improve strength, flexibility and stamina of her spine. As per the condition called as histocytosis basically body s immune system will be over active and there will be more inflammation in body which is damaging the normal body cells also. So here I suggest to do regular exercise, balance diet with more of anti inflammatory diet plan, proper rest, and positive mental attitude will also help her to improve. Take care.