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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How Much Dosage Of Metoprolol Can Be Fatal?

My brother is suffering from depression he also has high blood pressure and takes 50mg daily dose of metoprolol for this i discovered he has been hoarding this med, but i cannot gain easy access to it to remove it how many mg would be a lethal overdose for him? he is 58 years old, 220 lbs.
Mon, 5 Jan 2015
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General & Family Physician,  's  Response
Hello
Your brother is taking metoprolol ,a beta blockers 50 mg .
The maximum dose is 200 mg twice in day .
This drug produces BRADYCARDIA ( decrease in heart rate ) and hypotension.
But if more than 300 mg taken as a single dose abruptly it may be lethal depending on duration of time i.e. if taken first time may be lethal but if patient is taking for long duration then may tolerate 300 mg also .
But overall more than 500 mg is lethal in divided doses ,other wise 300 mg in a single dose is dangerous for life.
As far as about removal , because it act within 1 hour but higher the doses , the longer the duration 4 to 16 hours ( removal period).
Good luck.
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How Much Dosage Of Metoprolol Can Be Fatal?

Hello Your brother is taking metoprolol ,a beta blockers 50 mg . The maximum dose is 200 mg twice in day . This drug produces BRADYCARDIA ( decrease in heart rate ) and hypotension. But if more than 300 mg taken as a single dose abruptly it may be lethal depending on duration of time i.e. if taken first time may be lethal but if patient is taking for long duration then may tolerate 300 mg also . But overall more than 500 mg is lethal in divided doses ,other wise 300 mg in a single dose is dangerous for life. As far as about removal , because it act within 1 hour but higher the doses , the longer the duration 4 to 16 hours ( removal period). Good luck.