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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How To Switch From Vortioxetine To Sertraline?

HereI ve been on Brintellix (vortioxetine) for 5 weeks. First week 10mg, second week 20mg and I wasn t feeling well. I decided to reduce or even quit. I ve been on 5mg for about 3 weeks and in the last week I ve been feeling anxious and slightly spaced out.My GP doesn t know much about vortioxetine but has prescribed sertraline and advised to quit vortioxetine. I m concerned that the vortioxetine will still be in my system and wonder whether I might need to be off it completely for a few weeks before starting the sertraline? I m also worried about withdrawal symptoms from vortioxetine.Thanks for your help.
Sat, 7 Jul 2018
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General & Family Physician 's  Response
Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.

The process of switching should be gradual.
- reduce dosage of vortioxetine to 5 mg/day for eight days
- a wash-out period of 1 week is necessary
-then start sertraline.

Hope I have answered your query. Let me know if I can assist you further.

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How To Switch From Vortioxetine To Sertraline?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. The process of switching should be gradual. - reduce dosage of vortioxetine to 5 mg/day for eight days - a wash-out period of 1 week is necessary -then start sertraline. Hope I have answered your query. Let me know if I can assist you further.