Hi, My mother is 59 years old and having bilateral leg edema. She is not having any past medical history of DM, HTN etc. For the past 6 month she was monitoring the construction work actively and then she developed sudden moderate leg swelling and mild ankle pain. Visited an internal medicine specialist who suggested Banocide and doxycyclin 3:1 per day. After 10 days of taking the medicine, she had a blood test which revealed low creatinine level and asked to follow up with an internal medicine (nephro) specialist. Could you please let us know, if this is because of the current medicine that she is taking or any other underlying condition. thanks.