Hi! Thank you for your question and welcome to our site! TPO, or thyroid peroxidase, and thyroglobulin are produced by the thyroid for the production of active thyroid hormones. TSH, or thyroid stimulating hormone, is produced by your pituitary gland to signal the thyroid to produce thyroid hormones. In autoimmune diseases like Hashimoto s thyroiditis or Grave s disease, antibodies against TPO and thyroglobulin will decrease your active thyroid hormones, which in turn, increase your TSH (like what you had 2 months ago) because your body is detecting the low levels of thyroid hormone. Low thyroid hormone levels can affect many bodily functions including your periods because the thyroid hormone is important in regulating metabolism. Do continue taking your medications and make sure that you consult regularly with your physician for blood tests and to tweak your medications. Correcting your thyroid levels may take some time and even require some procedures depending on the disease severity but these are all very manageable. I hope I was able to address your concerns. Please do not hesitate to contact me for any further questions. Take care and I wish you better health! Dr. Galera