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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Ethambuttol And Pyridoxine The Right Treatment For Brain Meningitis?

modified att started since 18 may 14 for Brain meanigitis. Only Ethambuttol,Pyradoxine,Bi weekly streptomycin inj is being given till now.Patient is still feeling guidy sometimes.Pain remains on leg joints.Feels heated at feet s bottom.is treatment okay, as some suggest without refamcin ,it may adversely affect.
posted on Wed, 24 Sep 2014
Twitter Sat, 22 Nov 2014 Answered on
Twitter Mon, 24 Nov 2014 Last reviewed on
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Neurologist,  's  Response
Hello dear,
Modified ATT is antituberculous therapy modified usually in cases of renal failure and hepatic failure.It appears that in your case it has been modified due to liver injury as isoniazid,rifampicin and pyrazinamide,all three hepatotoxic drugs have been removed.In such a case,these drugs will be re-introduced gradually as the liver injury improves.With a liver injury,giving rifampicin and other 2 drugs,can lead to a fatal hepatic failure thus causing more damage than your tuberculous meningitis.So,let it be modified for the time your liver functions improve.I hope you got your answer.
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Is Ethambuttol And Pyridoxine The Right Treatment For Brain Meningitis?

Hello dear, Modified ATT is antituberculous therapy modified usually in cases of renal failure and hepatic failure.It appears that in your case it has been modified due to liver injury as isoniazid,rifampicin and pyrazinamide,all three hepatotoxic drugs have been removed.In such a case,these drugs will be re-introduced gradually as the liver injury improves.With a liver injury,giving rifampicin and other 2 drugs,can lead to a fatal hepatic failure thus causing more damage than your tuberculous meningitis.So,let it be modified for the time your liver functions improve.I hope you got your answer.