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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Increased Pramipexole Dosage Safe To Be Taken For Myoclonus?

I am a 74 y/o female who was diagnosed with myoclonus 3 years ago. My doctor added Pramapexole .25 mg three times per day to the previous .5 mg of ClonazaPam, since that alone was not working. Adding the Pram has made a huge difference in the severity & number of muscle jerks/jumps in my leg. My doctor wants to increase the Pramapexole to .5mg three times per day. I am wondering what effect this will have on my kidneys. I have taken the .5mg for two days now, and have not noticed any changes in urination. Thank you. e-mail: YYYY@YYYY
Wed, 21 Mar 2018
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Internal Medicine Specialist 's  Response
Hello,

Pramipexole belongs to dopamine agonists. The drug usually started from the lower dose and the dose increased gradually. It is usually well tolerated by the patients up to 4.5 mg/day dose. About 90% of the drug cleared from the body through the kidneys. Pramipexole does not affect your kidney function. It might cause up to 10% of patients urinary frequency, urinary tract infection, urinary incontinence. If a patient has an underlying kidney problem, the dose needs to be adjusted, according to kidney function.


Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Malik
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Is Increased Pramipexole Dosage Safe To Be Taken For Myoclonus?

Hello, Pramipexole belongs to dopamine agonists. The drug usually started from the lower dose and the dose increased gradually. It is usually well tolerated by the patients up to 4.5 mg/day dose. About 90% of the drug cleared from the body through the kidneys. Pramipexole does not affect your kidney function. It might cause up to 10% of patients urinary frequency, urinary tract infection, urinary incontinence. If a patient has an underlying kidney problem, the dose needs to be adjusted, according to kidney function. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Malik