Hi, There are some variations with Instaflex, there is instaflex joint support, instaflex advanced joint support and also a topical cream. The ingredients in the instaflex advanced joint support and instaflex joint support vary a bit. We can check cross reaction with the Percocet, and also check to see if it causes low blood sugar. According to Medscape drug interaction site- there are no direct interactions between percocet and the main ingredients of instaflex that are available there. However, on further check of some of the ingredients in Advanced joint support instaflex- (resveratrol), it was found that it can slow down the break down of a number of normal medications in the liver and therefore cause higher than normal levels of these meds in the blood , most concerning would be use of any blood thinners because of possible bleeding (eg: warfarin, aspirin, advil, cataflam etc). She would have to take care if using any of these. Bioperine- another ingredient can interact with these thinners as well. Instaflex is not known to cause low blood sugar, so it should not cause a problem with her diabetes. If you want to check interactions with her specific blood sugar meds, you can send their names and this can be done as well. So in sum, it is NOT known to affect blood sugar. It can affect breakdown to some medications particular concern with blood thinners. It is NOT known to interact with Percocet. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Michelle Gibson, General & Family Physician