Hi & Welcome. There is no documented harmful interactions between the two, hence they can be taken together under the supervision of your doctor. Based on the history you seem to be taking Amberen to counteract the effects of surgical menopause (post hysterectomy). Amberen is a dietary supplement which contains blend of succinates, amino acids, minerals and vitamin E that helps relieve most common symptoms of perimenopause and menopause by naturally restoring hormonal balance. It is a clinically tested dietary supplement but not approved by FDA for the treatment of post hysterectomy symptoms due to hormonal imbalance. However, the postmenopausal symptoms are usually best treated with the use of hormone replacement therapy in the form of estrogen and progestin combination. Endocet is a combination of Acetaminophen and Oxycodone that is used to relieve moderate to severe pain like in arthritis or due to a pinched nerve. Since there is no documented harmful interaction between Amberen and Endocet, they may be taken together under the supervision of your doctor. Hope this will help.