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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is It Safe To Take Hydrocodone Or Ultram Or NSAIDS With Savella?

I have had fibromyalgia since 1996. I now need an MRI for severe pain in lower back and legs (old horsewoman, lol) etc. I m really having a bad time of it. Can t sit, sleep, stand, you name it and can t get away from the pain for even a little while. My doctor is wanting me to try Savella and gave me the starter pack. I thought I had heard you cannot take hydrocodone or ultram or NSAIDS with Savella. Don t remember my doc saying not to, but want to know (since he is on a well deserved Christmas vacation), if under normal circumstances, the pain medications are compatible with Savella. I ve gone without any for 3 days (pain meds) and really, really hurt. I m very, very cautious with them as have seen way to many horror stories in my old line of work (nursing). Any advice would be appreciated.
posted on Fri, 14 Mar 2014
Twitter Thu, 30 Apr 2015 Answered on
Twitter Mon, 4 May 2015 Last reviewed on
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Orthopaedic Surgeon,  's  Response
Dear patient
Savella is selective serotonin and nor epinephrine reuptake inhibitor and falls in class of antidepressants but approved by FDA for fibromyalgia. It has very good results in fibromyalgia. It should be not used with nsaids as combined drug leads to increased risk of internal and external bleeding. So you should stop all nsaids before starting this drug to avoid interaction. All the best.
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Is It Safe To Take Hydrocodone Or Ultram Or NSAIDS With Savella?

Dear patient Savella is selective serotonin and nor epinephrine reuptake inhibitor and falls in class of antidepressants but approved by FDA for fibromyalgia. It has very good results in fibromyalgia. It should be not used with nsaids as combined drug leads to increased risk of internal and external bleeding. So you should stop all nsaids before starting this drug to avoid interaction. All the best.