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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is There Any Interaction Between Aspirin And Losartan?

Looking for advice on interactions of enteric coated aspirin and losartan potassium. I took both for only a month and a half. During that time, I experienced a couple of episodes of irregular and/or fast heart beats. Never had such episodes prior to or after taking the aspirin. Have been on losartan (75 mg/day) for 4 years. WebMd site clearly states possible negative interactions, but my doctor(s) say ok to continue on aspirin.
Wed, 20 May 2015
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General & Family Physician 's  Response
Thank you for asking on HCM

Combining Aspirin with Losartan may reduce the effects of Losartan in lowering blood pressure.

In addition, these medications may affect your kidney function, especially when they are used together frequently or chronically. You are more likely to develop impaired kidney function during treatment with these medications if you are also using a diuretic ("water pill") or if you are elderly or have preexisting kidney disease.

You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

See your doctor if you experience signs and symptoms that may suggest kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.

If your irregular heart beats persists a switch from Losartan to Atenolol 100mg half tablet twice daily may be required.


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Dr. Elton
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Is There Any Interaction Between Aspirin And Losartan?

Thank you for asking on HCM Combining Aspirin with Losartan may reduce the effects of Losartan in lowering blood pressure. In addition, these medications may affect your kidney function, especially when they are used together frequently or chronically. You are more likely to develop impaired kidney function during treatment with these medications if you are also using a diuretic ( water pill ) or if you are elderly or have preexisting kidney disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. See your doctor if you experience signs and symptoms that may suggest kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. If your irregular heart beats persists a switch from Losartan to Atenolol 100mg half tablet twice daily may be required. Kindly rate my answer as helpful. Dr. Elton