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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Seems That My T4 Is Low, Tsh High. Had Removed Thyroid. But Now Feel Worse. GFR Results Low. Problem?

Hello. I am very confused by all the information about the normal ranges for free t4 and tsh levels. My levels are free t4 1.3ng/dl and TSH 3.8. According, to the information on the web my t4 is low and tsh levels are high. My physician tells me there in normal range. I had my thyroid removed a year ago, due to having hashimotos disease and a goiter (thyroid 3x it size) and taking levothyroxine 88, but I feel worse now than before I had surgery. Also, My GFR results have been 760ml/min 1.7, which I think would equal something 34liters, which is low and means kidney damage stage three, since all my other GFR tests over the year has been close to the same range.
Tue, 25 Jun 2013
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General & Family Physician 's  Response
hello,
thank you for consulting HCM.As per your information given as you have underwent surgery and your thyroid has been removed,your t4 levels are low and as a copeup mechanism TSH levels will rise to increase t4 production and thats the reason your thyroid profile is in that picture.And coming to the GFR it indicates kidney disease so adequate treatment is needed so please consult nephrologist so that he will prescribe wanted investigations and will guide you further.THANK YOU.TAKE CARE.
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General & Family Physician Dr. S. Jegadeesan's  Response
Hello,
I went through your statements. Few points for your notice:
TSH is secreted by the pituitary gland in the brain. The secretion of TSH is adjusted according to the thyroid hormones in the blood. T4 is different from Free T4. Most of the thyroxine (T4) in the blood is attached to a protein called thyroxine-binding globulin. Less than 1% of the T4 is unattached. A total T4 blood test measures both bound and free thyroxine.
TSH - is the most important hormone and because of its value the thyroid function can be assessed. As per your statements the given thyroid hormone levels are normal and so for your reference normal values are given.
I think you are confused between Free T4 and Total T4
Total Thyroxin (T4) - 11.8-22.6 micrograms per deciliter (mcg/dL)
Free Thyroxin (FT4) - 0.7-2.0 ng/dL nanograms per deciliter (ng/dL)
TSH level - 0.4 to 6
You can compare yourself.
Regarding the GFR - I have a doubt about your statement results.
Normal kidney function result – GFR above 90mL to 120 ml/min/1.73m2 and no proteinuria.
If it is less than 90 it indicates your kidney is not functioning well. Kindly verify your GFR result.
Best wishes




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Seems That My T4 Is Low, Tsh High. Had Removed Thyroid. But Now Feel Worse. GFR Results Low. Problem?

hello, thank you for consulting HCM.As per your information given as you have underwent surgery and your thyroid has been removed,your t4 levels are low and as a copeup mechanism TSH levels will rise to increase t4 production and thats the reason your thyroid profile is in that picture.And coming to the GFR it indicates kidney disease so adequate treatment is needed so please consult nephrologist so that he will prescribe wanted investigations and will guide you further.THANK YOU.TAKE CARE.