Hello, Welcome to HCM. You have not mentioned in which area of the body she is suffering from allergy. Get her examined by a dermatologist. Is she having any other complications? She needs to be clinically detected for the allergy. Post-pill allergy after a long gap is a rare case ( though individual variations do occur ). Yes, Crisanta LS has side effects like cholasma, weight changes, mood changes , jaundice, skin reactions, liver function disorders, headache, nausea, menstrual, irregularities, G-I upset, cramps and pain in legs, vaginal discharge and cervical erosion depression, loss of libido, etc. I suggest you to let your wife have a medical check up done. It is best to check out her fitness. She should get LFT, and other investigations completed. Let her have home made nutritious diet, take care.