Sign-in to Ask A Doctor - 24x7
OR
Sign in with GoogleGet your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
Suffering From Epilepsy. Taking Medicines. Having Vitamin D Deficiency. Caused By Anti-epileptic Drugs?
I am suffering from Epelipsy since 2005 I am on Desval ER 750 mg + frisium 5 mg (morning) / Desval 500 mg + Ciplar LA 20 mg + Zorsart (Night) Is anti-epileptic drugs that are often given to epilepsy patients can interfere with vitamin D metabolism , leading to deficiency. My Vitamin D level as of now is 27.11 ng/nl . For vitamin D I am taking Cholecalciferol Granules Due to the deficiency of Vitamin D my company will be deducting 10% of my total pay . I found out through my neuro surgeon that Vitamin D increases gradually in Epileptic patients. I need to confirm that does Sodium Valproates can sap our body of vitamin D, folic acid, and maybe even calcium. Need to give an explanation to my company.
Mon, 15 Apr 2013
Sodium valproate can cause vit D deficiency with the resultant calcium deficiency as vitamin D is needed for the calcium metabolism and vitamin D deficiecy leads to calcium deficiency.
Data on valproate (VPA) effects on folic acid are conflicting. Most authors report that valproate does not reduce folate levels but may interfere with folate metabolism by inhibiting glutamate formyl transferase, an enzyme mediating the pathway that produces folinic acid
Data on valproate (VPA) effects on folic acid are conflicting. Most authors report that valproate does not reduce folate levels but may interfere with folate metabolism by inhibiting glutamate formyl transferase, an enzyme mediating the pathway that produces folinic acid
I find this answer helpful
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer.
For a more detailed, immediate answer, try our premium service
[Sample answer]
Related questions you may be interested in
Recent questions on Calcium deficiency
Loading Online Doctors....