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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Alternative Medicine For Quazepam

Hello Dr, Grief. I appreciate your time in answering my questions. I am a long term user of quazepam ( Doral 15mg). Apparently this medication is no longer manufactured in the United States. However, through web searches. (Wikipedia) , I have found the following: Quazepam is unique amongst benzodiazepines in that it selectively targets the GABAA a1 sub unit receptors which are responsible for inducing sleep. Its mechanism of action is very similar to zolpidem and zaleplon in its pharmacology and can successfully substitute for zolpidem and zaleplon in animal studies.[6][7][8] First question, since Quazepam targets the GABAAa1 Receptors, and I function perfectly well on this medication, either my nervous system is not producing GABAAa1 (or the chemical produced in the body that binds with this site), or my nervous system is not up taking it. So, what is supposed to be occurring that quazepam takes the place of? Second question: are there any medications that can do the same job as quazepam? If so, what are the names of them? Third Do you know whether either Zolpidem or Zaleplon is available in the USA? If so where? Thanks, Karl
Thu, 7 May 2015
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General & Family Physician 's  Response
HI, thanks for using healthcare magic

Zolpidem is also known as ambien, zaleplon is known as sonata and these are available at most pharmacies.You may known them better with these names.
You may need a prescription but can ask your pharmacist.

The mechanism of action is not indicating that you are deficient in GABA in any way.
GABA affects alertness and by targeting this, it can affect your ability to sleep.

I hope this helps
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Suggest Alternative Medicine For Quazepam

HI, thanks for using healthcare magic Zolpidem is also known as ambien, zaleplon is known as sonata and these are available at most pharmacies.You may known them better with these names. You may need a prescription but can ask your pharmacist. The mechanism of action is not indicating that you are deficient in GABA in any way. GABA affects alertness and by targeting this, it can affect your ability to sleep. I hope this helps