Hi Thanks for posting First of all we need to find out the cause of your suffering by getting blood test done for serum RA factor, ANA test,Anti CCP antibody test and serum uric acid. For osteoarthritis, weight reduction is the main treatment. Life style modifications like avoiding sitting cross legged; squatting will decrease the rate of progression of osteoarthritis. Exercises like ankle movement with or without resistance, swimming; straight leg rising will help in improving the muscle strength around the ankle and will help in decreasing pain. My advice would be take glucosamine for your ankle osteoarthritis, the recommended dose of glucosamine sulphate is 1500mg and chondroitin sulphate is 800-1200mg daily in divides doses. Glucosamine by nutralite is a good brand and with balanced composition. This is usually given for 3 months and then 6 months off after there is symptomatic improvement. This is not a pain killer so additional medicines are required for pain control and optimum joint activity. In case you have additional questions or doubts, you can forward them to me, and I shall be glad to help you out. Wishing you good health. Regards. Take care Dr.chugh http://bit.ly/drmchugh