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Suggest New Combination Of Drugs For Parkinson S Disease
What drug or combinations of drugs are being used with the greater success in controlling symtoms. My dr. In 2009 Prescribed Azilect one time a day, trihexyphenidyl three times a day. Currently, I m taking cardidopa/ladopa 25/100 mg. 1 1 /2 in the morning and two rest of day, selegiline one a day and two trihexyphenidyl. I was a firefighter for 34 years and I retired 07.. First symptom was my left leg did not move on demand when I was putting. I still play golf today. Mr doctor is amazed. After ten years I can turn, barely ever have tremors in left hand etc. bad symptoms curling my toes on left foot with digging into ground. Also, wobbling Of hips mainly in lower legs. Plus drooling , skin dryness and getting out of bed. What new drug could becoming in the future that will help all Parkinson s patients with symptoms.
posted on
Fri, 20 Oct 2017
Medically reviewed by
Ask A Doctor - 24x7 Medical Review Team
Thu, 18 Oct 2018
Answered on
Mon, 22 Oct 2018
Last reviewed on
Hi,
There is a newer drug in the market which is called RYTARY and is combo drug using carbidopa and levodopa in an extended release form. There are extended release formulations such as Sinemet CR and ODT which either release medication slowly (CR) or immediately (ODT).
These can have benefits in different populations of patients. Also, there is a carbidopa/levodopa PUMP which is likely the most rapid and best way to have medication dosed since it is a constant release formulation directly into the GI tract which gives patients a pill free existence.
Finally, DBS is a surgical procedure which has shown excellent success in many patients who do not do well with conventional therapy. Unfortunately, there is nothing on the horizon at this point that is likely going to address every concern or consequence of not having enough dopamine produced by the brain.
What I've mentioned may be a step up for many patients compared to the conventional therapies of the last 10 years. From what you've described your symptoms may actually respond either very well or potentially better than what you currently are taking by considering either DBS or Dopamine Pump therapy.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Dariush Saghafi,
Neurologist
There is a newer drug in the market which is called RYTARY and is combo drug using carbidopa and levodopa in an extended release form. There are extended release formulations such as Sinemet CR and ODT which either release medication slowly (CR) or immediately (ODT).
These can have benefits in different populations of patients. Also, there is a carbidopa/levodopa PUMP which is likely the most rapid and best way to have medication dosed since it is a constant release formulation directly into the GI tract which gives patients a pill free existence.
Finally, DBS is a surgical procedure which has shown excellent success in many patients who do not do well with conventional therapy. Unfortunately, there is nothing on the horizon at this point that is likely going to address every concern or consequence of not having enough dopamine produced by the brain.
What I've mentioned may be a step up for many patients compared to the conventional therapies of the last 10 years. From what you've described your symptoms may actually respond either very well or potentially better than what you currently are taking by considering either DBS or Dopamine Pump therapy.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Dariush Saghafi,
Neurologist
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