hi thanks for asking as looking to your history (frequent urination with difficulty holding urine) it is typical presentation of urinary tract infection..........i would like to ask 1) is there any fever or chills and rigors??? 2) which medicine and for how much time you have taken previously??? 3) are you male or female??? after this you will need to do investigations like full blood count,urine RE and ultrasound abdomen and pelvis (with full bladder).......and most important urine for Culture and sensitivity test ( because your bacteria might be resistant to certain antibiotics) treatment consists of (in consultation with your doctor) 1) painkiller tablets 2) antibiotics based on urine CS 3) urine alkalnizer e.g sachet citrosoda three times daily ( in glass of water) 4) and most importantly plenty of water