Dear Dr. Topiwala, I was diagnosed with Graves disease in March 2010. My doctor put me on 100mg of ptu twice a day. I did a blood test 6 weeks later and the free t3 and t4 were normal however the tsh was 0.01. My doctor told me to remain on the same ptu dosage of 100mg twice a day. I then moved to another city due to my husband changing jobs. I had to wait for two months before I did another blood test, because I had to wait for my new insurance.So my latest results were: TSH 2.140, Free T4 0.79, Free T3 2.1 . My next appointment with my endocrinologist is not before 3 weeks, and I would like to know how much ptu I should take. I m sure that I should decrease the dosage as I m feeling a bit sleepy, tired, and lethargic all the time. Please, I would appreciate your feedback as I m so confused and can t wait for three more weeks until I see my endocrinologist. Thank you so much. Celine