Dear Doctor I am a hypothyroid patient which was detected very late. In my first report TSH was approx. 78 & started medicines but still having constipation problem. After sometime I started having high pulse rate (i.e. mostly above 100). Last 3 years all my doctors have tried to find out reason for high pulse rate but were not successful. I was even hospitalised for 5 days for investigation cause my heart beat was more than 150. Now I am just dragging on with my problems & have lost faith that I will feel normal again. I have the following symptoms : feel very weak, constipated, I get cold & cough again & again, have some burning feeling in my body, loss of hair, I get exhausted very quickly, heavyness in chest, Body pain, can t eat spicy food etc. I did not have any health related problem earlier even my doctors have told me that I am not having any heart related problem. My heart specialist had asked to do a thyroid scan to find out if I had infection in thyroid gland but the doctor who was treating me refused to do thyroid scan. But yes many a times my ESR is high & once a doctor told me that some times heart beat is high due infection also. If we think that yes I am having some infection in my body how to find out that where the infection is ? Should I get a thyroid scan done ? In my recent report ESR is 25 (0-20) & TSH is 12.38 (0.3 - 5.0). High TSH shows that I should increase the dose of thyroid tablet. Right now I am taking 50mcg tab for 2 days & 25mcg on the third day. If I increase dose I feel very uneasy & again my pulse goes higher. According to a doctor my thyroid dose is OK she says sometimes TSH also goes high because of infection. We do not have any thyroid history in the family but now my brother is also suffering same things like me & in his first report his TSH was approx. 300. Please help & suggest something to find out some solution. Thanks & Regards