My problem begin around April this year. I had visited my primary doctor for a few times and did not solve my problem. So I try to solve by myself by looking all of my blood test result and searching from internet. My beginning problem is waking up in the early morning (only sleep 3 hours) about 2:30 am when feel the shoulder joint bone reducing and it disappear right away after standing up no more sleep and it come again when I go to bed to sleep again. After one month it developed to litter pain on shoulder to wake me up in the early morning. My doctor said that my thyroid function is normal because TSH 2, T4 0.85 . the vitamin d 28.9 little lower but I already took the vitamind3 2000iu more per day and my doctor said it is about enough vitamin d3 now but my problem even become more serious. I then went to emergency room because feel stress sex needed , short breath, and high blood pressure . Doctor want me bring all of the blood test result back to see my primary doctor. He did not say anything but no infection . I feel I am dying and no help because the following days is independent day and holiday. By overview my blood test I had found Sodium 135 (lower), Potassium (3.3) lower, Chloride95(lower), CO2 (25) normal, Anion Gap 15 (higher). I think I am lack of electrolyte, and buy the electrolyte concentrate to dilute with water to drink. After I drink a big cup of electrolyte water I feel much better no more stress. I continue my internet search about why short electrolyte and found that I need take more sea salt food and potassium food and I continue to search why Anion Gap higher. I had found my blood pressure medicine losartan may cause RTA and cause Anion Gap higher. After I take off my blood pressure medicine losartan and take amlodipine in stead of it , my shoulder pain disappear that night (My blood pressure medicine is amlodipine 5mg and losartan 50mg generally, now I change to take amlodipine 10 mg ). I had solved my shoulder pain but I still wake up in the early morning can not sleep enough. I think I might have Hypothyroid problem. By self-test of early morning 1st wake up temperature of my body , 95.2 F , 95.1F, 95.F. From the book if the body temperature in this self test is lower than 97F is hypothyroid. So I think now my problem is hypothyroid . I am looking for how to solve my condition. Thank you for reading and looking forward to your advice. f