I ve been on Seroquel XR 250 for several years. Over that time I have gained around 70 lbs. My primary doctor, my cardiologist, my pulmonary doc, my psychiatrist etc. all want me to lose weight, so do I. I have been following a sound balanced diet (not calorie restricted which is counter-productive). I also am walking approx. 1/2 mile 2x/week and swimming 1/3 mile 2x/week. Since I started this routine January 21, 2017 I have lost 7 lbs. It is an uphill battle. In conversations with providers and pharmacists, they have all pretty much said that any medication like Seroquel will have the same side-effects. Are you aware of any suitable substitute I can discuss with my doctor without this side-effect (wt gain)? Thanks.