Hi, SIR THANKS FOR SERVING OUR COUNTRY !, A salute from civilian. Lets, start with understand what do we mean by POLYNEUROPATHY , NERVES are like electric wire conducting the information from one point/ part to the brain and back, now nerve like electric wires have a insulation, but due to various reason the insulation layer gets withered and so the nerves will have issue concealing the information with the secure track (like short circuit as in case of electric circuit), and the information will be misrepresented as pain instead of mild touch or in matter of fact even heat can be represented by damage nerve to brain as PAIN. This is major issue in polyneuropathy, its not yet possible to entirely replace the lost insulation of the nerve. Now cause for polyneuropathy are various as well as the treatment varies with different cause, Following are the causes and available treatment, 1) Diabetic polyneuropathy - treat diabetes and keep sugar in control and give pain medication for symptoms of pain. 2) Alcoholic polyneuropathy- Stop alcohol consumption , pain medication for pain if needed. 3) Familial amyloid polyneuropathy - Tafamidis (only approved by european union not by FDA yet) 4) polyneuropathies due vitamin deficiency - vitamin replacement. + pain medication for pain if needed 5) Autoimmune polyneuropathies - Immuno- suppression therapy, + pain medication for pain if needed. *********************************************************************************YES so the METHADONE AND OXYCODONE will help if taken correctly and thanks for the COMMENT.