My 76 yr old father has dementia,diabetes,chf,light copd,asthma. In the last 4-6 weeks he has developed a rash/hives over his body. None of the doctors seem to know what is causing it. We have tried benadryl, hydroxzine, kenalog cream, and has had 3 cortisone shots in last 3 weeks. The shot stops itching for a day and a half maybe then it comes back. He has been taking metoprolol for about 18 to 20yrs, could he have developed a reaction suddenly?