Hi, I hope you are well. Infection with Clostriddium Difficile is a condition that is increasingly increasing, this may be due to the excessive increase in the use of antibiotics. The infection can originate associated with the use of antibiotics causing a diarrhea that can be from mild to fulminant. The antibiotics mainly associated are clindamycin, fluoroquinolones, cephalosporins, macrolides, among many others, as well as hospitalizations. For its diagnosis requires an appropriate interrogation, clinical suspicion, hematical biometry, liver chemistry, serological tests, stool study and depending on the situation and severity of imaging studies ranging from abdominal radiographs to abdominal CT scans. For your treatment, you must first suspend the possible antibiotics involved or modify by another less harmful scheme. Only patients who present with diarrhea are eligible for treatment since asymptomatic carriers do not benefit from treatment. The two main therapeutic options are metronidazole and vancomycin, in both cases the route of administration is oral, according to the severity may be as monotherapy or if they are together metronidazole can be administered by IV. The duration lasts 10-14 days or until suspending the associated antibiotics in case they could not be removed or modified.