Hello there, I am dr.milan an infectious disease specialist answering your question. I suggest you to follow treatment guidelines of your physician. Increased leucocyte count found when there is infection or any inflammation. You have not specified your wife is pregnant or not, if pregnant you should consult a gynecologist for safe drug prescription in pregnancy along with physician. Once antibiotic given blood culture in most of the cases is found negative. Just check your culture report is done by a reliable microbiology lab and by a qualified doctor microbiologist. Once you complete drug course if you have infection it may get clear than your count will be decreased. If after completion of drug course, count is not decreasing than you should check dou you have any infection related symptoms? if no any symptoms and count is high than it must be some inflammatory type of response. So you need to worry than. If any symptoms like fever than immediately consult your doctor and go for blood culture at that time it may found some organism in blood and your report will be positive. Hope i have given appropriate guidance to you. if you have any query you can consult me anytime. Give me star rating, helpful vote & thank you according to your satisfaction level. Thanking you.