What Causes Burning, Stabbing Pain In The Knee And Extending To Thigh And Hips?

I was diagosed with MS. in 2007. I ve been experiencing burning, stabbing pain in my left knee (my left side is my weak side). Pain starts with my knee and shoots up my left thigh to hip. I ve had this issue over the years, but nothing as bad as this. Pain happens mostly when I m laying down. I work full time, was just in bed for 3 days due to pain & still having problems walking. Per my bone & joint Dr., i have fluid on my left wrist and a lump of fluid on the outside of my left wrist that shoots a pain up my arm at any given time. He recommends physical therapy for my wrist. Are the 2 issues connected? It s hard to use crutches due to the shooting pain in my wrist. Are these MS related. What can I do? I already take too many pills for fatigue, etc.